Nelville Flynn escorts a witness onto a plane headed for Los Angeles. Problem is, an assassin who is bent on killing the witness has released a crate containing about 450 snakes onto the same plane. Nelville finds out and he's bent on doing his job and getting the snakes back where they belong; on land. Or in snake heaven, where they'd be harmless. But can he get the snakes off the plane before it's too late?