A virus with no cure. A threat with no borders. A nation with no chance of escaping H5N1, the Avian Flu. When a mutationof the virus is discovered in a local marketplace, China sends an emergency summonsto Dr. Iris Varnack (Joely Richardson) of the Epidemic Intelligence Service. When she arrives, she discovers her efforts may be too late - an American businessman has become thefirst victim of a strain that's passed from human to human. As the flu begins its insidious spread, Secretary of Health and Human Services Collin Reed (Stacy Keach) races to combat the ensuing choas. The victim's wife, Denise Connelly (Ann Cusack), does what she can do to help other infected people. It wasn't supposed to happen this way - untill it did.