Fresh off the success of their inventive take on the zombie genre, Undead masterminds Michael and Peter Spierig direct Ethan Hawke in an ambitious tale of a futuristic Earth populated entirely by vampires, and the efforts made by the creatures to ensure that their food supply doesn't run out as humankind is faced with extinction. The year is 2017, and a vampire plague has turned most of the planet's human population into bloodsucking ghouls. As the population of mortals fast begins to dwindle, a vampiric corporation sets out to capture and farm every remaining human while simultaneously researching a consumable blood substitute, headed by undead hematologist Edward Dalton Ethan Hawke. His work is interrupted after stumbling onto a pocket of human survivors lead by Elvis Willem Dafoe, a former vampire, whose past reveals a cure that could reverse the tide and save the human race. With time running out, Dalton's only hope lies in outsmarting the security forces of his boss Sam Neill, whose goal isn't just to find a substitute, but to repopulate humanity in order to sell its blood to the highest bidder.